Alec Baldwin

Theodore Templeton (voice)

Steve Buscemi

Francis E. Francis (voice)

Miles Bakshi

Tim Templeton (voice)

Jimmy Kimmel

Ted Templeton (voice)

Lisa Kudrow

Janice Templeton (voice)

Tobey Maguire

Narrator / Older Tim Templeton (voice)

Conrad Vernon

Eugene Francis (voice)

James McGrath

Wizzie / Elvis Impersonator (voice)

David Soren

Jimbo (voice)

Nina Zoe Bakshi

Tim's Daughter / Girl / Little Girl (voice)

Tom McGrath

TV Chef (voice)

Walt Dohrn

Photographer (voice)

James Ryan

Story Bear (voice)

Eric Bell Jr.

Triplets (voice)

ViviAnn Yee

Staci (voice)

Edie Mirman

Big Boss Baby (voice)

James Izzo

Elvis impersonator (voice)

Chris Miller

Captain Ross (voice)

Chloe Albrecht

Hazmat Baby (voice)

Andrea Montana Knoll

Flight Attendant (voice)